Biologic therapies in severe/uncontrolled asthma

In collaboration with

Acknowledgement of Commercial Support
This activity is supported by an educational grant from Regeneron

Title: Biologic therapies in severe/uncontrolled asthma

Release | Expiration: December 19, 2025 – December 19, 2026

Statement of Need:
Biologic therapies targeting IgE, IL-5, IL-4Rα, and TSLP have reshaped the landscape for severe asthma, allowing for personalized, phenotype-driven care. These agents offer options for patients who remain symptomatic despite maximal inhaled therapy. Several biologics are currently approved, with dupilumab and tezepelumab among the most recent additions. This expanded toolkit offers flexibility in treatment selections, yet it can also make decisions more complicated for asthma specialists and primary care providers alike.

Specialists, including allergists and pulmonologists, lead in diagnosing complex cases, conducting phenotyping, and initiating biologic therapy.  However, they are often unsure how to choose among the available biologics, particularly when indications overlap, or patient profiles vary. Questions also remain around when to switch agents, taper therapy, or apply biomarker data to personalize long-term care.

This curriculum has been developed for asthma specialists and will focus on optimizing the use of biomarkers and treatment algorithms to personalize biologic selection, sequencing, and de-escalation strategies in complex or refractory asthma cases.

Educational Objective:

DIFFERENTIATE among currently approved asthma biologics based on patient phenotype, biomarker profiles, and clinical indications to select the most appropriate therapy for individualized care
 

Target Audience:
Allergy, Immunology and Pulmonology clinicians (MDs, DOs and APPs)

Faculty:

	Karla E. Adams, MD, FAAAAI, FACAAI, FAAP Professor of Pediatrics Uniformed Services University Bethesda, MD Program Director, Allergy and Immunology Fellowship Wilford Hall Ambulatory Surgical Center Lackland Air Force Base, TX
Disclosures	Dr. Adams has no relevant disclosures

Technical Writer:
Lynne Kolton Schneider, PhD

Disclosures
No relevant financial disclosures

Jordana Goldman, MD

Disclosures
No relevant financial disclosures

Accredited Provider Disclosure:
None of the planners, reviewers, and AAAAI and RealCME staff for this educational activity have relevant financial relationship(s) with ineligible companies to disclose.

Disclosure of Financial Relationships Policy:
AAAAI adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CME/CE activity, including faculty, planners, reviewers, or others are required to disclose all financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Accredited Provider & Accreditation Statements:
This activity is accredited through AAAAI. 

CME: The American Academy of Allergy Asthma and Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CE: The American Academy of Allergy Asthma and Immunology (AAAAI) is a Provider approved by the California Board of Registered Nursing, Provider #10704.

Credit Designation Statement:
The AAAAI designates this activity for up to 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use:
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a clinician relative to diagnostic and treatment options for a specific patient's medical condition.

Disclaimer:
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AAAAI and RealCME. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

If you have any questions relating to the accreditation of this activity, please contact cme@aaaai.org

Method of Participation/Instructions:
Please proceed with the activity until you have successfully completed this program, answered all test questions, and evaluation, and have received a digital copy of your credit certificate.

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