Multiple Sclerosis Highlights from the 2019 National Neurology Conference

Multiple Sclerosis Highlights from the 2019 National Neurology Conference
0.5 AMA PRA Category 1 Credit(s) 0.5 ANCC Contact Hours
Launch Date:
June 27, 2019
Expiration Date:
The accreditation for this activity has expired.

Primary Audience:


Relevant Terms:

MRI, McDonald Criteria, Investigational Drugs, Disease Modifying Therapies

Christina J. Azevedo, MD, MPH

Assistant Professor of Clinical Neurology
Keck School of Medicine of USC
Los Angeles, California

Dr Christina Azevedo is assistant professor of neurology at the University of Southern California. She specializes in multiple sclerosis and other autoimmune disorders of the central nervous system.

Dr Azevedo earned her bachelor of science degree from the University of Notre Dame and her medical degree from Oregon Health & Science University. She completed her neurology residency at Dartmouth, her Sylvia Lawry fellowship in clinical MS and Neuroimaging at Yale, and her master’s degree in public health at Yale with a focus on applied biostatistics and epidemiology.  Her research focuses on the identification and validation of MRI-based surrogate markers for neurodegeneration for use in phase 2 and 3 clinical trials for progressive MS.  She has received research and training support from the National Multiple Sclerosis Society, the Race to Erase MS Foundation, and the NIH-funded University of Southern California Clinical Translational Science Institute. She is a member of the American Academy of Neurology and the Alpha Omega Alpha Medical Honor Society.

Patricia K. Coyle, MD

Director, MS Comprehensive Care Center
Professor of Neurology
Stony Brook Neurosciences Institute
Stony Brook, New York

Patricia K. Coyle, MD, is professor and acting chair of neurology and the director of the Multiple Sclerosis Comprehensive Care Center at the Stony Brook University Medical Center, Stony Brook, New York. She received a BS degree with highest honors from Fordham University, Bronx, New York, and an MD degree from the Johns Hopkins School of Medicine, where she was elected to Alpha Omega Alpha. While at the Johns Hopkins she completed a residency and chief residency in neurology, followed by a two-year fellowship in neuroimmunology and neurovirology. She then went on to establish a successful research laboratory in addition to building a busy clinical practice at the Stony Brook University Medical Center. Dr Coyle is the author of numerous articles on clinical and basic research aspects of MS and neurologic infections and she is recognized as a leading expert on MS and neurologic infections. Her areas of expertise include Lyme disease, cerebrospinal fluid, therapeutics, neuroimmunology, and fatigue. Her research has been supported by the National Institutes of Health and other organizations. She is currently involved in a number of therapeutic trials testing new immunotherapies for MS, as well as studies addressing neurologic aspects of Lyme disease. In addition to her busy clinical and research careers, she has held active leadership positions in a number of national and international organizations and academic societies, including the American Academy of Neurology, American Neurological Association, and National MS Society. She is a director of the American Board of Psychiatry and Neurology. She lectures widely on MS and neurologic infections to national and international audiences. 

Robert Fox, MD

Staff Neurologist
Mellen Center for Multiple Sclerosis
Cleveland Clinic
Cleveland, Ohio

Robert Fox, MD, is a staff neurologist at the Mellen Center for Multiple Sclerosis at Cleveland Clinic. He received his medical degree from Johns Hopkins University, neurology residency training at the University of Pennsylvania, multiple sclerosis fellowship training at Cleveland Clinic, and a master’s degree in clinical research from Case Western Reserve University. He serves as an advisory committee member and principal site investigator for many clinical trials. Dr. Fox’s current research interests focus on innovative MRI techniques to evaluate MS treatments and tissue recovery after injury, where he is principal investigator and co-investigator on grants funded by the NIH and National MS Society. He serves as a member of various advisory and review committees for the National MS Society. He is also managing director of the NARCOMS MS Patient Registry, a member of the General Advisory Council and Research Programs Committee for the Cleveland Clinic General Clinical Research Center, and a consultant to the pharmaceutical industry regarding the development of new treatments for MS.

Stephen Krieger, MD

Stephen Krieger, MD
Associate Professor of Neurology
Corinne Goldsmith Dickinson Center for MS
Icahn School of Medicine at Mount Sinai
New York, New York

Stephen Krieger joined The Corinne Goldsmith Dickinson Center for MS as a fellow in multiple sclerosis after completing his neurology residency training at Mount Sinai. He was the recipient of a 2006 American Academy of Neurology Scholarship and received a Sylvia Lawry Fellowship in clinical research from the National Multiple Sclerosis Society. He was graduated from Columbia College and received his MD degree from Yale University. Dr Krieger has a clinical practice at the Center and has participated in numerous MS clinical trials, including oral therapies and monoclonal antibodies used as disease modifying agents for MS. In addition to his clinical work, he has an academic appointment as associate professor of neurology at the Icahn School of Medicine at Mount Sinai, where he is director of the neurology residency training program. He has also served as director of the Brain and Behavior seminar series for the medical school. Dr Krieger was elected as a Faculty Member of Alpha Omega Alpha and inducted as a Fellow into the Institute for Medical Education in 2011, and has received several subsequent teaching and mentorship awards including the George Forster Compassion Award in 2014. Dr Krieger is on several advisory boards and steering committees in the field of MS and is an active member of the American Academy of Neurology (AAN), which awarded him an A.B. Baker teaching recognition award in 2010. He has presented original work at AAN, CMSC, ACTRIMS, and ECTRIMS and has written review articles on and lectures nationally about MS with an emphasis on emerging therapies. In 2015, Dr Krieger proposed the topographical model of MS, a new conceptualization of MS disease course that was accepted for presentation at several national/international meetings and was the subject of an article in Scientific American

1. Describe the current understanding of multiple sclerosis disease phenotypes and their relevance to clinical practice.
2. Review the clinical utility of results from recent research in available and emerging disease modifying therapies for the treatment of multiple sclerosis.
3. Discuss the clinical and radiographic findings that are consistent with – or inconsistent with – a diagnosis of multiple sclerosis.

This continuing education activity was developed from interviews with the faculty during a live national neurology conference. The faculty acknowledge the editorial assistance of Global Academy for Medical Education, LLC, and medical writer Ron Schaumburg, in the development of this supplement.

Copyright © 2019 by Global Academy for Medical Education, LLC, Frontline Medical Communications Inc. and its Licensors. All rights reserved. No part of this publication may be reproduced or transmitted in any form, by any means, without prior written permission of the Publisher. Global Academy for Medical Education, LLC, the accredited provider or the Publisher will not assume responsibility for damages, loss, or claims of any kind arising from or related to the information contained in this publication, including any claims related to the products, drugs, or services mentioned herein.

This activity is jointly provided by Global Education Group and Global Academy for Medical Education.

Term of Offering

This activity was released on 6/27/2019 and is valid for one year. Requests for credit must be made no later than 6/27/2020.

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Participants should read the activity information, review the activity in its entirety, and complete the online post-test and evaluation. Upon completing this activity as designed and achieving a passing score on the post-test, you will be directed to a Web page that will allow you to receive your certificate of credit via e-mail or you may print it out at that time.

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Physician Credit Designation

Global Education Group designates this enduring material for a maximum of .50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Disclosure of Conflicts of Interest

Global Education Group (Global) requires instructors, planners, managers, and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. 

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity: 

Christina J. Azevedo, MD, MPH: 
Consultant: Biogen IDEC, Novartis, and Sanofi Genzyme

Patricia K. Coyle, MD: 
Consultant: Accordant, Actelion, Alexion, Bayer, Biogen, Celgene, Genentech/Roche, Genzyme/Sanofi, Novartis, Serono, and TG Therapeutics. Grant/Research Support: Actelion, Alkermes, Genentech/Roche, MedDay, NINDS, and Novartis.

Robert J. Fox, MD: 
Consultant: Biogen, EMD Serono, Genentech, Genzyme, Mallinkrodt, MedDay, Novartis, Teva, and TG Therapeutics. Grant/Research Support: Novartis.

Stephen Krieger, MD FAAN: 
Consultant: Actelion, Biogen, EMD Serono, Genentech, Novartis, and Teva. Honoraria: Biogen and Novartis.

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity: 

Global Academy for Medical Education Staff: Shirley V. Jones, MBA; Mike LoPresti, Ron Schaumburg, have nothing to disclose.

Global Education Group: The following planners and managers, Ashley Marostica, RN, MSN; Andrea Funk; Liddy Knight; Ashley Cann and Lindsay Borvansky, have nothing to disclose.

Fee Information& Refund/Cancellation Policy

There is no fee for this educational activity.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Global Education Group (Global) and Global Academy for Medical Education do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. 

Supporter Acknowledgement

This activity is supported by an educational grant from Genentech.



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