Improving CARE of Patients With Sleep Disorders: Etiology-Based Management Strategies for ES

2 AMA PRA Category 1 Credit(s)
Launch Date:
October 28, 2014
Expiration Date:
The accreditation for this activity has expired.

Primary Audience:

Neurologists, Nurse Practitioners, Physician Assistants, Primary Care Physicians, Sleep Specialist

Relevant Terms:

Sleep Disorders, Sleep Medicine

Phyllis C. Zee, MD, PhD

Phyllis C. Zee, MD, PhD
Professor of Neurology, Neurobiology, and Physiology
Northwestern University Feinberg School of Medicine
Director, Sleep Disorders Center
Northwestern Memorial Hospital
Chicago, IL

Phyllis C. Zee is the Benjamin and Virginia T. Boshes Professor in Neurology and Director of the Sleep Disorders Center at Northwestern Universitys Feinberg School of Medicine in Chicago, Illinois, where she is also Associate Director of the Center for Sleep and Circadian Biology.

Dr. Zee directs an interdisciplinary clinical and research program in sleep and circadian rhythms. Research topics in this Program range from basic animal studies to therapeutic clinical trials. Basic and clinical studies from her laboratory paved the way to novel treatments for disorders associated with sleep and circadian clock dysfunction. Her research has focused on the effects of age on sleep and circadian rhythms, genetic regulation of circadian sleep disorders, and behavioral interventions to improve sleep and performance. In addition, current NIH sponsored research include studies that examine the relationship between sleep and sleep disorders with metabolic and cardiovascular risk in populations at risk, such as older adults, and the effects of sleep disturbance on adverse pregnancy outcomes. Dr. Zee also has authored more than 100 peer reviewed original articles and over 40 chapters and reviews on the topics of sleep, circadian rhythms, and sleep/wake disorders.

A fellow of the American Academy of Sleep Medicine, fellow of the American Academy of Neurology and member of the American Neurological Association, Dr. Zee has served on numerous national and international committees, NIH scientific review panels, and advisory boards. She is President of the Sleep Research Society, past Chair of the NIH Sleep Disorders Research Advisory Board, and A Deputy Editor for the journal SLEEP. Dr. Zee is the recipient of the 2011 American Academy of Neurology Sleep Science Award.

Paul P. Doghramji, MD

Paul P. Doghramji, MD
Family Physician
Collegeville Family Practice
Collegeville, PA

Paul P. Doghramji completed a medical degree at Jefferson Medical College in Philadelphia. His postdoctoral training included a residency in family practice at Chestnut Hill Hospital, also in Philadelphia. Dr. Doghramji cofounded Brookside Family Practice & Pediatrics, an affiliate of Pottstown Medical Specialists, in Pottstown, Pennsylvania. He has also been Attending Physician in Family Practice, Chair of the Utilization Management Committee, and Physician Advisor at Pottstown Memorial Medical Center; Senior Staff Member at Collegeville Family Practice; Assistant Medical Director for Health Services at the Hill School in Pottstown; and Preceptor in the Physician Assistant Program at Arcadia University in Glenside, Pennsylvania. Board certified by the American Board of Family Practice, recertified 4 times since then, and a Fellow of the American Academy of Family Physicians, Dr. Doghramji holds membership in the American Academy of Physicians, and has held membership in the American Medical Association, the National Headache Foundation, and the Chronic Fatigue and Immune Dysfunction Syndrome Association. Dr. Doghramji has received the American Medical Association Physician Recognition Award in all qualifying years since leaving residency. Dr. Doghramji’s work on sleep medicine has been published in Postgraduate Medicine, Journal of Clinical Psychiatry, INSOM Magazine, and International Journal of Clinical Practice, as well as on such Web sites as Medscape and Pri-Med. He coauthored a textbook, Clinical Management of Insomnia, released January 2007. Dr. Doghramji lectures nationally on topics relating to sleep medicine.

Emmanuel Mignot, MD, PhD

Emmanuel Mignot, MD, PhD
Professor of Psychiatry and Behavioral Sciences
Stanford University
Director, Stanford University Center for Sleep Sciences
Palo Alto, CA

Dr. Emmanuel Mignot is Professor of Psychiatry and Behavioral Sciences at Stanford University and Director of the Stanford Center for Sleep Sciences and Medicine. He is internationally recognized for discovering the cause of narcolepsy. Dr. Mignot is a former student of the Ecole Normale Superieure (Ulm, Paris, France). He received his M.D. and Ph.D. from Paris V and VI University in France. He practiced medicine and psychiatry in France for several years before serving as a visiting scholar at the Stanford Sleep Disorders Clinic and Research Center. He joined as faculty and Director of the Center for Narcolepsy in 1993. He was named Professor of Psychiatry in 2001 and Director of the newly established Stanford Center for Sleep Sciences and Medicine in 2010.
Dr. Mignot has received numerous research grants and honors, including National Sleep Foundation and National Institute of Health Research Awards, Howard Hughes Medical Institute Investigator and McKnight Neuroscience awards, the Narcolepsy Network professional service award, the Drs. C. and F. Demuth 11th Award for Young Investigators in the Neurosciences, the WC Dement Academic Achievement Award in sleep disorders medicine, the CINP and ACNP awards in neuropharmacology and the Jacobaeus prize. He is an elected member of the Association of American Physicians, the Institute of Medicine, and of the National Academy of Sciences (USA).
He is the co-author of more than 200 original scientific publications, and he serves on the editorial board of scientific journals in the field of sleep and biology research. Dr. Mignot is an active member of several professional and governmental organizations. He has been President of the Sleep Research Society, Chair of the National Center on Sleep Disorders Research Advisory board of the National institutes of Health, and Chair of the Board of Scientific Counselors of the National Institute of Mental Health.
1. Describe the neurobiology of sleep and ES
2. Characterize the behavioral, physiologic, and biopsychosocial consequences of ES in patients with disorders commonly encountered in neurologic practice
3. Conduct a differential diagnosis of sleep disorders based in part on medical, psychiatric, and sleep histories; symptomatology; validated questionnaires; and objective laboratory findings
4. Explain how to implement evidence-based management plans specifically designed to treat the identified sleep disorders or disturbances in patients with diverse neurologic disorders

Target Audience
This activity has been designed to meet the educational needs of physicians, physician assistants, and nurse practitioners in the field of neurology and sleep medicine.

Program Overview
The overall aim of this program is to improve accuracy of diagnosis of patients with excessive sleepiness (ES), highlighting the specific etiologies that can manifest as ES in neurology practice and selecting management strategies targeted appropriately to achieve the best possible outcomes for patient care.

Physician Accreditation Statement
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Global Education Group (Global) and HealthmattersCME. Global is accredited by the ACCME to provide continuing medical education for physicians.
Physician Credit Designation
Global Education Group designates this enduring activity for a maximum of 2.0 AMA PRA Category 1 Credits™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Fee Information & Refund/Cancellation Policy
There is no fee for this educational activity.
For information about the accreditation of this program, please contact Global at 303-395-1782 or
Disclosure of Conflicts of Interest
Global Education Group (Global) requires instructors, planners, managers and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and HealthmattersCME do not recommend the use of any agent outside of the labeled indications. 
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Instructions to Receive Credit
In order to receive credit for this activity, the participant must complete the online post-test, with a passing score of 70% or higher, and the online evaluation form.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:
Name of Faculty or Presenter Reported Financial Relationship
Paul P. Doghramji, MD Consultant/Independent Contractor:
AstraZeneca, Merck, Teva Pharmaceutical
Industries LTD.
Speaker’s Bureau:
Takeda, Teva Pharmaceutical Industries
Emmanuel Mignot, MD, PhD Dr Mignot has no real or apparent
conflicts of interest to report, nor any
financial relationships to disclose.
Phyllis C. Zee, MD, PhD Consultant/Independent Contractor:
Aptalis; Jazz Pharmaceuticals; Merck;
Vanda Pharmaceuticals, Inc.
Grant/Research Support:
Philips Respironics
Stock Shareholder:
Teva Pharmaceuticals
Name of Planner or Manager Reported Financial Relationship
Andrea Funk Nothing to disclose
Amanda Glazar, PhD Nothing to disclose
Ashley Marostica, RN, MSN Nothing to disclose
James Murphy Nothing to disclose

This activity is jointly sponsored by Global Education Group and HealthmattersCME.

This activity is supported by an independent educational grant from Jazz Pharmaceuticals.

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